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Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene

✍ Scribed by Hua-Guo Xu; Rui Jin; Wei Ren; Li Zou; Yi Wang; Guo-Ping Zhou

Book ID: 116309571
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 773 KB
Volume: 94
Category: Article
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2012.03.011

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## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same