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The characterisation of the human Wolfram syndrome gene promoter demonstrating regulation by Sp1 and Sp3 transcription factors

✍ Scribed by Christopher Ricketts; Malgorzata Zatyka; Timothy Barrett


Book ID
113485485
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
946 KB
Volume
1759
Category
Article
ISSN
0167-4781

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## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same