Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor
โ Scribed by J. Robert Lane; Elisabeth Klaasse; Judy Lin; John van Bruchem; Margot W. Beukers; Adriaan P. IJzerman
- Book ID
- 113489291
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 274 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The synthesis and the preliminary biological evaluation of the first high affinity radioligand antagonist for the human A3 adenosine receptor, named [3H]-MRE 3008-F20 are reported. [3H]-MRE 3008-20 bound human A3 receptors expressed in CHO cells with K(D) and Bmax value of 0.82 +/- 0.08 nM and 297 +
## thio-2-propyl]-2-chloroadenosine (NNC 21-0136) is a novel adenosine agonist with neuroprotectant properties in rodent models of focal and global ischemia that exhibits diminished cardiovascular side effects when compared to reference A 1 agonists [Sheardown et al., 1995]. NNC 21-0136 is shown t