Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation
β Scribed by Kanoe, Hiroshi; Nakayama, Tomitaka; Hosaka, Taisuke; Murakami, Hiroshi; Yamamoto, Hiroshi; Nakashima, Yasuaki; Tsuboyama, Tadao; Nakamura, Takashi; Ron, David; Sasaki, Masao S
- Book ID
- 110061820
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 420 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract __RUNX1__ rearrangements are common genetic abnormalities in acute leukemia. The t(7;21)(p22;q22) translocation, recently described in three cases of myeloid neoplasias, fuses the ubiquitin specific peptidase 42 gene, __USP42__, a member of the deubiquitinating enzyme family, to __RUNX1
The transcription factor gene CHOP was recently shown to be rearranged in myxoid liposarcoma with t( 12; I6)(q I );p I I). We have analyzed whether the CHOP gene is the target of rearrangements in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses with chromosome abnormalities of