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Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation

✍ Scribed by Kanoe, Hiroshi; Nakayama, Tomitaka; Hosaka, Taisuke; Murakami, Hiroshi; Yamamoto, Hiroshi; Nakashima, Yasuaki; Tsuboyama, Tadao; Nakamura, Takashi; Ron, David; Sasaki, Masao S


Book ID
110061820
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
420 KB
Volume
18
Category
Article
ISSN
0950-9232

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The transcription factor gene CHOP was recently shown to be rearranged in myxoid liposarcoma with t( 12; I6)(q I );p I I). We have analyzed whether the CHOP gene is the target of rearrangements in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses with chromosome abnormalities of