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The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma

✍ Scribed by Dr. Göran Stenman; Pelle Sahlin; Joachim Mark; R. S. K. Chaganti; Lars-Gunnar Kindblom; Pierre Åman

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 294 KB
Volume: 7
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870070312

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✦ Synopsis

The transcription factor gene CHOP was recently shown to be rearranged in myxoid liposarcoma with t( 12; I6)(q I );p I I). We have analyzed whether the CHOP gene is the target of rearrangements in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses with chromosome abnormalities of 12q I 3-q 15. Restriction fragment analysis showed that the CHOP gene and its flanking sequences were not rearranged in any of these tumor types, indicating that the 12q translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma are different from that in myxoid liposarcoma Genes Chrorn Cancer 7: 178-180 (1993).

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Translocation t(12;22)(q13;q12.2–12.3) in a clear cell sarcoma of tendons and aponeuroses

✍ Dr. Krzysztof Mrózek; Constantine P. Karakousis; Carlos Perez-Mesa; Clara D. Blo 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

## Abstract Cytogenetic analysis of a short‐term culture from a clear cell sarcoma revealed a complex karyotype with the mainline of 49,XY,t(7;18)(p11.2;q21.3), + der(7)t(7;18)(p11.2;q21.3), + 8, + der(8;17)(q10;q10),t(12;22)(q13;q12.2–12.3),add(13)(p13). An apparently identical translocation t(12;