Two variants of the TLS-CHOP fusion transcript in myxoid liposarcomas with the 12;16 translocation
✍ Scribed by Ioannis Panagopoulos; Pierre Åman; David Ron; Mattias Höglund; Nils Mandahl; Felix Mitelman
- Book ID
- 113253504
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 91 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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It is well established that the majority of myxoid/round cell liposarcomas (LPS) are characterized by a reciprocal translocation t(12;16)(q13;p11) which at the molecular level results infusion of the CHOP and FUS/TLS genes. It is assumed that functional characterization of these genes may provide in
Most myxoid liposarcomas (MLS) are characterized cytogenetically by a t( 12; I6)(q I3:p I I). It is reasonable t o assume that this translocation corresponds t o the consistent rearrangement of one o r t w o genes in 12q I 3 and/or I6p I I, and that the loci thus affected are important in the normal