Characteristics and significance of the amorphous state in pharmaceutical systems
β Scribed by Bruno C. Hancock; George Zografi
- Book ID
- 109388617
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 366 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0022-3549
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In this study, we have examined the acid-base characteristics of various citrate buffer systems alone and in the presence of the pH indicator dye, bromophenol blue, in aqueous solution, and after lyophilization to produce amorphous material. Fourier transform Raman and solid-state nuclear magnetic r
The aim of this work is to determine if a stability testing protocol based on the correlations between crystallization onset and relaxation time above the glass transition temperature (T(g)) can be used to predict the crystallization onsets in amorphous pharmaceutical systems well below their T(g).