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Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide

✍ Scribed by John M Ridley; James T Milnes; Andrew V Benest; Joe D Masters; Harry J Witchel; Jules C. Hancox

Book ID: 117054063
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 210 KB
Volume: 306
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(03)00980-x

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## Abstract A number of clinically used drugs block delayed rectifier K^+^ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltage‐dependent inhibition of human ether‐__a‐go‐go__‐related gene (HERG)