Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine
β Scribed by So-Young Lee; Young-Jin Kim; Kyong-Tai Kim; Han Choe; Su-Hyun Jo
- Book ID
- 110009134
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 442 KB
- Volume
- 148
- Category
- Article
- ISSN
- 0007-1188
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## Abstract A number of clinically used drugs block delayed rectifier K^+^ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltageβdependent inhibition of human etherβ__aβgoβgo__βrelated gene (HERG)
SUMMARY: The airways relaxant effects and mechanism of action of the potassium channel activators BRL 38227 and pinacidil have been compared in guinea-pig and human airways. BRL 38227 was a potent relaxant in guinea-pig isolated trachealis ( \(\mathrm{IC}_{50}=4.9 \times 10^{-7} \mathrm{M}\) against