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Changes in p14ARF do not play a primary role in human chondrosarcoma tissues

✍ Scribed by Julia Asp; Camilla Brantsing; Maria Serena Benassi; Sven Inerot; Luca Sangiorgi; Piero Picci; Anders Lindahl

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 106 KB
Volume: 93
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.1398

No coin nor oath required. For personal study only.

✦ Synopsis

The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14(ARF), has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the first unique exon, exon 1 beta, of p14(ARF), has been studied in 22 chondrosarcoma tissues using polymerase chain reaction, DNA sequencing and methylation-specific polymerase chain reaction. One chondrosarcoma was found to have exon 1 beta homozygously deleted, but neither mutations nor methylations were found in any of the chondrosarcomas. This indicates that genetic changes of p14(ARF) are a rare event in chondrosarcoma.

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