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Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice

โœ Scribed by Jill A. Rafael; Jeffrey I. Trickett; Allyson C. Potter; Kay E. Davies

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
189 KB
Volume
22
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

The loss of full-length dystrophin from skeletal muscle leads to the clinical features of Duchenne muscular dystrophy. Both Dp71, a Cterminal dystrophin isoform, and the dystrophin-related protein, utrophin, are present at high levels in many nonmuscle tissues. To investigate the roles of these proteins in nonmuscle tissues, mice were generated null for utrophin, and deficient in all dystrophin isoforms. These mice reach adulthood and do not appear to have any devastating pathology in nonmuscle tissues.

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