Changes in Chromosomes of Bone Marrow after Intravenous Injections of 7,12-Dimethylbenz(a)anthracene and Related Compounds
β Scribed by E. Douglas Rees, S. K. Majumdar and Amy Shuck
- Book ID
- 123649567
- Publisher
- National Academy of Sciences
- Year
- 1970
- Tongue
- English
- Weight
- 909 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/59944
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## Abstract The present study has investigated the antigenotoxic effect of withaferinβA, a steroidal lactone obtained from the roots and leaves of __Withania somnifera__, in 7,12βdimethylbenz(a)anthracene (DMBA)βinduced genotoxicity. Measurement of the frequency of micronucleated polychromatic eryt
The frequency of chromatid breaks associated with sister chromatid exchanges at the break point was determined in rat bone marrow cells treated in vivo with 7-12 DMBA, during the late S phase of the cell cycle. The chromosomal aberrations and SCEs were scored in the same cells. Under the experimenta