Antigenotoxic effect of genistein against 7,12-dimethylbenz[a]anthracene induced genotoxicity in bone marrow cells of female wistar rats
β Scribed by Pugalendhi, Pachaiappan; Manoharan, Shanmugam; Panjamurthy, Kuppusamy; Balakrishnan, Subramanian; Nirmal, Madhavan R.
- Book ID
- 122315157
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 128 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1734-1140
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## Abstract The present study has investigated the antigenotoxic effect of withaferinβA, a steroidal lactone obtained from the roots and leaves of __Withania somnifera__, in 7,12βdimethylbenz(a)anthracene (DMBA)βinduced genotoxicity. Measurement of the frequency of micronucleated polychromatic eryt
The frequency of chromatid breaks associated with sister chromatid exchanges at the break point was determined in rat bone marrow cells treated in vivo with 7-12 DMBA, during the late S phase of the cell cycle. The chromosomal aberrations and SCEs were scored in the same cells. Under the experimenta