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Localisation of 7-12-Dimethylbenz(a)anthracene induced chromatid breaks and sister chromatid exchanges in chromosomes 1 and 2 of bone marrow cells of rat in vivo

✍ Scribed by A. C. Kesteren-van Leeuwen; A. T. Natarajan

Publisher: Springer
Year: 1980
Tongue: English
Weight: 878 KB
Volume: 81
Category: Article
ISSN: 0009-5915
DOI: 10.1007/bf00368157

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✦ Synopsis

The frequency of chromatid breaks associated with sister chromatid exchanges at the break point was determined in rat bone marrow cells treated in vivo with 7-12 DMBA, during the late S phase of the cell cycle. The chromosomal aberrations and SCEs were scored in the same cells. Under the experimental conditions employed, more than 40% of the chromarid breaks were found to be associated with an SCE, a frequency expected according to Revell's hypothesis for the formation of chromatid breaks.

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