Cesium Fluoride Catalyzed Trifluoromethylation of Esters, Aldehydes, and Ketones with (Trifluoromethyl)trimethylsilane. -The title reaction is successfully applied to carboxylic, sulfonic, sulfinic, and selenic esters, and also to aldehydes and ketones, among them substrates that have been reported
Cesium Fluoride Catalyzed Trifluoromethylation of Esters, Aldehydes, and Ketones with (Trifluoromethyl)trimethylsilane
β Scribed by Singh, Rajendra P.; Cao, Ganfeng; Kirchmeier, Robert L.; Shreeve, Jean'ne M.
- Book ID
- 120042811
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 123 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane
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