Direct Preparation of Trifluoromethyl Ke
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JΓΌrgen Wiedemann; Thomas Heiner; Gregorz Mloston; G. K. Surya Prakash; George A.
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Article
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1998
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John Wiley and Sons
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English
β 72 KB
Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane