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ChemInform Abstract: Synthetic Methods and Reactions. Part 201. Direct Preparation of Trifluoromethyl Ketones from Carboxylic Esters: Trifluoromethylation with (Trifluoromethyl)trimethylsilane.

✍ Scribed by J. WIEDEMANN; T. HEINER; G. MLOSTON; G. K. S. PRAKASH; G. A. OLAH


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
29
Category
Article
ISSN
0931-7597

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Direct Preparation of Trifluoromethyl Ke
✍ JΓΌrgen Wiedemann; Thomas Heiner; Gregorz Mloston; G. K. Surya Prakash; George A. πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 72 KB

Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane