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Ceric ammonium nitrate promoted free radical cyclization reactions leading to β-lactams

✍ Scribed by Andrea D'Annibale; Antonella Pesce; Stefano Resta; Corrado Trogolo

Book ID
104256535
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
245 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The reaction of enamides with CAN in methanol affords variously functionalized 13-1actams through a 4-exo-trig c3.,clizalion of ot-carbamo.vlalkyl radicals; in most cafes products with trans stercochemistry can be obtained.

📜 SIMILAR VOLUMES

ChemInform Abstract: Ceric Ammonium Nitr
ChemInform Abstract: Ceric Ammonium Nitrate Promoted Free Radical Cyclization Reactions Leading to β-Lactams.
✍ A. D'ANNIBALE; A. PESCE; S. RESTA; C. TROGOLO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Ceric Ammonium Nitrate Promoted Free Radical Cyclization Reactions Leading to β-Lactams. -Treatment of enamides (I) or (V) with cerium ammonium nitrate (CAN) generates α-carbamoyl radicals which undergo 4-exo-trig cyclization followed by methanol quenching to provide the functionalized β-lactams. T