Cerebral Ischemia: Molecular and Cellular Pathophysiology

✍ Scribed by Costantino Iadecola (auth.), Wolfgang Walz (eds.)

• Publisher: Humana Press
• Year: 1999
• Tongue: English
• Leaves: 279
• Series: Contemporary Neuroscience
• Edition: 1
• Category: Library

✦ Synopsis

In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions.
Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today.

✦ Table of Contents

Front Matter....Pages i-ix
Front Matter....Pages 1-1
Mechanisms of Cerebral Ischemic Damage....Pages 3-32
Front Matter....Pages 33-33
Spreading Depression Waves as Mediators of Secondary Injury and of Protective Mechanisms....Pages 35-44
Cell Swelling in Cerebral Ischemia....Pages 45-67
Calcium Overload....Pages 69-104
Oxygen Radicals....Pages 105-123
Mechanisms of Neuroprotective Cytokines....Pages 125-142
Front Matter....Pages 143-143
Reprogramming of Gene Expression After Ischemia....Pages 145-215
Neurons....Pages 217-232
Reactive Astrogliosis in the Injured and Postischemic Brain....Pages 233-249
Activated and Phagocytic Microglia....Pages 251-269
Back Matter....Pages 271-278

✦ Subjects

Neurology