β Scribed by M. D. OβBrien (auth.), Professor Dr. Alexander Hartmann, Professor Dr. Wolfgang Kuschinsky (eds.)
No coin nor oath required. For personal study only.
Although many books deal with isolated problems of calcium disturbance in relation to cardiac and cerebral function, this is the first to focus specifically on calcium metabolism and cerebral ischemia. Internationally acknowledged experts present recent data and new concepts in an interdisciplinary approach to the subject. They examine basic information on the pathophysiology of cellular events, the damage caused by excitotoxic substances, and the effects of calcium antagonistic drugs as measured in experimental animals. These contributions may help lead to possible therapeutic interference for the prevention of calcium imbalance.
Front Matter....Pages I-XV
Front Matter....Pages 1-1
Academic Hemianopia and the Treatment of Cerebrovascular Disease....Pages 3-6
The Classification of Calcium Antagonists....Pages 7-15
Pharmacological Activities of Calcium Antagonists: Therapeutic Applications and Adverse Reactions....Pages 16-28
Cellular Movements and Distribution of Calcium....Pages 29-36
Front Matter....Pages 37-37
New Methods for Topographical Imaging of Physiologically Defined Boundary Zones in Focal Cerebral Ischemia....Pages 39-43
Experimental Hypoglycemia: Correlation Between EEG Abnormalities and Structural Alterations....Pages 44-51
Blood-Brain Barrier Permeability to Micromolecules After Focal Cerebral Ischemia....Pages 52-59
Mediation of Platelet and Coagulation Events by Blood Flow: Basic Mechanisms of Thrombosis in Cerebral Ischemia....Pages 60-68
Altered Cerebral Collaterals and Protection from Infarction....Pages 69-78
Physical Activity Determines Survival of Mongolian Gerbils from Forebrain Ischemia....Pages 79-82
Immunocytochemical Studies on Some Brain Regions in a Rat Model of Incomplete Cerebral Ischemia. Relationship to Behavior and Aging....Pages 83-96
Effects of Transient Global Cerebral Ischemia on Peptide Neuronal Populations in Different Brain Regions and on Behavioral Performances in Rats....Pages 97-104
Related Responses Between Dopamine Synapses and Astrocytes in the Rat Striatum After Global Cerebral Ischemia: A Morphometric and Microdensitometric Study....Pages 105-110
The Effects of Transient and Long-Term Ischemia on Tissue PO 2 in the Brain Cortex....Pages 111-119
Vasomotor Response and Blood-Brain Barrier Function of Rat Brain Studied in a Closed Cranial Window Preparation....Pages 120-123
Regional Cerebral Blood Flow After Cryoinjury of the Rabbit Brain....Pages 124-128
Front Matter....Pages 129-129
Calcium Antagonists in Brain Ischemia β Experimental Observations....Pages 131-138
In Vivo Fluorometric Measurement of Changes in Cytosolic Free Calcium from the Cat Cortex During Anoxia, Ischemia, and Postischemic Reperfusion....Pages 139-149
Calcium Antagonists and a Rapid Shift of Water from Extracellular to Intracellular Space After Cerebral Ischemia....Pages 150-154
A Fluorometric Technique for the In Vivo Measurement of Intracellular Calcium....Pages 155-161
Front Matter....Pages 129-129
Calcium Movements in Brain During Failure of Energy Metabolism....Pages 162-168
Glutamate Antagonism as a Pharmacological Approach to Prevent Calcium Influx in Focal Cerebral Ischemia....Pages 169-176
Calcium Antagonists and Experimental Focal Cerebral Ischemia....Pages 177-186
Effect of Calcium Antagonists on Cerebral Blood Flow, Protein Synthesis, and Histopathology After Global Ischemia of Gerbil Brain....Pages 187-195
The Effects of a Dihydropyridine Calcium Antagonist on Cerebral Blood Flow with and without Middle Cerebral Artery Occlusion....Pages 196-205
Nimodipine Binding in Cerebral Ischemia....Pages 206-209
Calcium Overload and Brain Damage in Stroke-Prone Spontaneously Hypertensive Rats: Prevention by Nimodipine and by Parathyroidectomy....Pages 210-214
Neurotransmitters and Calcium During Hypoxia....Pages 215-222
Protective Effects of Calcium Antagonists Against Brain Damage Caused by Ischemia....Pages 223-231
Ultrastructural Calcium Cytochemistry in the Study of Ischemic Brain Injury....Pages 232-239
Roles of Calcium-Activated Enzymic Reactions in Ischemia-Induced Neuronal Injury....Pages 240-244
The Effects of Experimental Anoxia on Glycolysis, Energy Status, Cytosolic Free Calcium, and Glutamate Release from Isolated Nerve Terminals....Pages 245-256
Ionized Free Calcium Concentration and Deformability in Platelets....Pages 257-265
Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers....Pages 266-273
Vascular and Direct Effects on Cerebral Energy Metabolism of Emopamil....Pages 274-281
Cytoprotective Characteristics of Dihydropyridine Calcium Antagonists in a Rat Model of Stroke: Implications for Clinical Trials....Pages 282-291
Effect of Diltiazem on the Cortical Microcirculation in Acutely Produced Cerebral Ischemia in Cats....Pages 292-298
Comparison of the Effects of Flunarizine and Nimodipine on Cerebral and Temporal Arteries with Comments on Their Clinical Use in Cerebrovascular Disorders....Pages 299-306
The Effect of Calcium Antagonists in Experimental Atherosclerosis, the Underlying Cause of Heart and Cerebral Vascular Diseases....Pages 307-312
Thrombosis on Stenosis: Mechanisms of Thrombus Growth and Embolization on Carotid Atherosclerotic Plaques....Pages 313-322
Front Matter....Pages 129-129
Suppression of Brain and Adrenal Gland Arteriosclerosis by Calcium Antagonism in Hypertensive Rats (Skelton Hypertension)....Pages 323-327
Extracellular Ion Activities During Ischemia and Reperfusion of the Rat Brain: Influences of Drugs....Pages 328-336
Front Matter....Pages 337-337
Density of Functioning Cerebral Capillaries in Stroke Patients, Determined by PET....Pages 339-349
Nimodipine Clinical Trial in Acute Ischemic Stroke....Pages 350-357
Nimodipine in Acute Ischemic Stroke: A Controlled Trial....Pages 358-361
Calcium Blocker Therapy in Acute Ischemic Stroke....Pages 362-366
A Pilot Study of Nicardipine for Acute Ischemic Stroke. The Nicardipine Study Group....Pages 367-372
An Open Study with Intravenous Application of Flunarizine in Acute Stroke....Pages 373-377
CBF Decreases in Ischemic Areas After Calcium Antagonist Treatment in Acute Stroke....Pages 378-383
The Effect of Nimodipine on ICP and CBF in the Awake Patient....Pages 384-388
Front Matter....Pages 389-389
Calcium Entry Blockers in Migraine: The State of the Art....Pages 391-397
Nimodipine, a Calcium Entry Blocker, Platelets, and Migraine....Pages 398-402
Treatment of Acute Migraine Attacks with Intravenous Flunarizine....Pages 403-409
Treatment of Migraine and Cluster Headache with Calcium Antagonists....Pages 410-418
Calcium Entry Blockers in Migraine Prophylaxis β A Critical Review of Therapeutic Trials....Pages 419-425
Front Matter....Pages 427-427
Calcium, Neuronal Hyperexcitability, and Ischemic Neuronal Injury....Pages 429-439
Calcium Accumulation in Ischemia and Seizures: Cause or Result of Cell Death?....Pages 440-448
Aspects of Calcium Ions in Cortical Spreading Depression....Pages 449-457
Depression of Focal and Generalized Tonic-Clonic Epileptic Activity by the Organic Calcium Antagonist Verapamil....Pages 458-461
Flunarizine, a Useful Adjuvant for Therapy-Resistant Epilepsy Patients....Pages 462-469
Front Matter....Pages 427-427
Review of Flunarizine in Epilepsy....Pages 470-479
Front Matter....Pages 481-481
The Effects of Flunarizine on Survival Following Prolonged Cerebral Ischemia in the Gerbil....Pages 483-493
Cerebroprotective Effects of a Parenteral Flunarizine Formulation....Pages 494-500
Studies on the Efficacy and Mechanism of Action of a Calcium Blocker After Global Ischemia....Pages 501-508
Calcium Antagonists in Acute Cerebral Damage: Therapy or Risk for the Brain?....Pages 509-518
Front Matter....Pages 519-519
Calcium Channel Blockade in Cerebral Vasospasm....Pages 521-526
Cerebral Ischemia Following Subarachnoid Hemorrhage β The Efficacy of Nimodipine as Therapy....Pages 527-546
Treatment of Symptomatic Cerebral Vasospasm After Subarachnoid Hemorrhage by Intraarterial Perfusion with Nimodipine....Pages 547-555
Effect of Nimodipine on CO 2 Reactivity of Patients with Normal and Spastic Basal Cerebral Arteries: A Transcranial Doppler Ultrasound Study....Pages 556-562
Treatment of Subarachnoid Hemorrhage with Oral Nimodipine: Preliminary Report of the British Aneurysm Trial....Pages 563-567
Front Matter....Pages 569-569
Impaired Calcium Homeostasis and Calcium Antagonists in Muscle Diseases....Pages 571-578
Back Matter....Pages 579-588
Neurology; Neurosurgery; Neurosciences
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