โ Scribed by M. D. OโBrien (auth.), Professor Dr. Alexander Hartmann, Professor Dr. Wolfgang Kuschinsky, Professor Dr. Siegfried Hoyer (eds.)
No coin nor oath required. For personal study only.
In contrast to dementia of the Alzheimer type, the subject of dementia subsequent to cerebral ischemia has been discussed rather rarely. Now this book provides a summary of the brain morphology, neurochemistry and clinical aspects of dementia subsequent to cerebral ischemia. The contributions discuss the similarities and differences between the two predominant dementia types. The broad range of aspects cover 1) the morphology and morphobiology of brain tissue during aging and under the two pathological condi- tions, 2) the neuropathochemistry of post mortem brain tissue of patients as well as brain tissue from experimental animals, 3) CSF changes during aging and in dementia states and 4) clinical research, mainly using brain imaging tech- niques to differentiate between dementia types and to find a basis for rational therapeutic approaches.
Front Matter....Pages I-XV
Front Matter....Pages 1-1
How Does Cerebrovascular Disease Cause Dementia?....Pages 3-6
Front Matter....Pages 7-7
The Epidemiology of Vascular Dementia....Pages 9-15
Epidemiology of Vascular Dementia and Stroke in Akita, Japan....Pages 16-24
Dementia in Stroke Survivors....Pages 25-30
Front Matter....Pages 31-31
The Anatomical Substrate of Ischemic Vascular Dementia....Pages 33-38
Vascular Dementia: The Search for a Correlate....Pages 39-53
Incomplete Infarction Is an Important Component in Cerebrovascular Dementia....Pages 54-59
Front Matter....Pages 61-61
Molecular Biology of Atherothrombotic Brain Infarction and Its Role in Vascular Dementia....Pages 63-68
Cellular Aspects of Atherosclerosis and Approaches to Intervention: A Mechanism to Reduce Stroke and Vascular Dementia Risk....Pages 69-76
Inhibition of Atherogenesis In Vivo and In Vitro....Pages 77-84
Front Matter....Pages 85-85
Alzheimerโs Disease: Role of Energy Metabolism and Treatment of Symptoms....Pages 87-93
Neurochemical Changes in Brains from Patients with Vascular Dementia....Pages 94-102
Subcortical Changes Following Ischaemic and Other Lesions of Cerebral Cortical Structures: Trophic Mechanisms and Neuronal Degeneration....Pages 103-120
Front Matter....Pages 121-121
Selective Vulnerability of the CA1 Sector in the Gerbil After 5 Minutes of Global Ischemia: Relationship to Disturbances in Protein Synthesis and to Motor Hyperactivity....Pages 123-131
Energy Metabolism in Cortex and Hippocampus During Aging, Ischemia, and Dementia....Pages 132-148
Mechanisms of Glial Swelling from Lactacidosis and High K + Levels in the Extracellular Compartment....Pages 149-156
Potential Mechanisms Underlying Protection Against Cerebral Ischemia by Spontaneous Locomotion in Mongolian Gerbils....Pages 157-160
Glutamate: A Role in Both Cerebral Ischaemia and Dementia of the Alzheimer Type....Pages 161-172
Sabeluzole Enhances Spontaneous EEG Activity and SSEP, and Accelerates Their Posthypoxic Recovery in Rat....Pages 173-182
Front Matter....Pages 183-183
Linkage Analysis in Italian Pedigrees with Autosomal Dominant Familial Alzheimerโs Disease....Pages 185-186
Front Matter....Pages 183-183
RBC Aggregation Is Not a Primary Factor for Microvascular Stasis on Temporary Complete Ischemia of the Feline Brain....Pages 187-192
White Blood Cell Behavior in the Cerebral Microcirculation....Pages 193-196
Improved Learning with N -Methyl- D -aspartate Receptor Antagonist After Global Cerebral Ischemia....Pages 197-201
Electrophysiological Markers of the Early Stages of Alzheimerโs Disease....Pages 202-216
Front Matter....Pages 217-217
Neuropsychological Assessment of Demented Patients....Pages 219-224
Multiinfarct and Microinfarct Dementia....Pages 225-233
Acute Aphasia....Pages 234-243
Front Matter....Pages 245-245
Cerebral Hemodynamics in Patients with Periventricular White-Matter Lesions on Brain Imaging....Pages 247-254
The Relation of Stroke to Leukoaraiosis....Pages 255-259
Computed Tomographic Evaluation of the Cervical Carotid Artery....Pages 260-265
Magnetic Resonance Imaging and Spectroscopy: A Unique Approach to Ischemic Cerebrovascular Disease....Pages 266-275
Imaging Techniques and Neuropsychological Testing in Dementia with Severe White Matter Changes....Pages 276-284
Front Matter....Pages 285-285
Cerebral Ischemia Correlates Better with Cognitive Impairments in Mild to Moderate Multi-Infarct Dementia than Infarcted Brain Volume....Pages 287-295
Regional Cerebral Blood Flow in Binswangerโs Disease....Pages 296-302
Front Matter....Pages 303-303
Cognitive Utilization of Cerebral Vasomotor Reserve in Cerebrovascular Disease....Pages 305-309
Tomographic Measurements of Regional Cerebral Blood Flow by SPECT in Vascular Dementia....Pages 310-315
Contribution of HM-PAO-SPECT and 133 Xe-rCBF to the Differential Diagnosis of Dementia as Experienced in Clinical Practice....Pages 316-321
Intracerebral Reserve Assessment with SPECT: Reactivity to Acetazolamide and Cerebral Blood Volume Measurement....Pages 322-326
SPECT Brain Imaging in Chronic Stroke and Dementia: A Comparison of 99m Tc-ECD and 99m Tc-HMPAO....Pages 327-333
CSF ฮฑ 1 -Antichymotrypsin and Antitrypsin in Multi-Infarct Dementia and Alzheimerโs Disease....Pages 334-337
Front Matter....Pages 339-339
Functional Recovery After Cerebral Ischemia: Studies in the Motor System....Pages 341-346
Detection of Structural and Metabolic Changes of the Brain in Normal Aging and Dementia with Modern Imaging Techniques....Pages 347-359
Subcortical Lesions and Dementia: The Role of Positron Emission Tomography....Pages 360-367
PET Metabolic and Neuropsychological Correlates of Periventricular Lucencies....Pages 368-373
Front Matter....Pages 375-375
Accuracy of the Antemortem Diagnosis and Neuropathological Features of Multi-Infarct Dementia....Pages 377-381
Development and Evaluation of the Maudsley Mentation Scale for Bedside Measurement of Fluctuations in Cognitive Function in Patients with Acute Vascular Lesions: Comparison with the Glasgow Coma Scale....Pages 382-385
Acute Confusional States After Stroke: Occurrence, Determinants, and Neuroendocrine Correlates....Pages 386-394
The Prognosis of Stroke in the Elderly....Pages 395-399
Thalamic Dementia and Pseudodementia....Pages 400-403
Front Matter....Pages 405-405
Positron Emission Tomography in Cerebrovascular Disease: Implications for Therapy?....Pages 407-415
A Clinical Trial of Pentoxifylline in Vascular Dementia....Pages 416-423
Rheological Therapy of Vascular Dementia: A Rational Basis?....Pages 424-431
Monosialoganglioside in Subarachnoid Hemorrhage....Pages 432-434
GM 1 Ganglioside Therapy in Acute Ischemic Stroke....Pages 435-441
Communicating Hydrocephalus โ Diagnosis and Management....Pages 442-445
Assessment of CSF Volume in Normal Subjects and Patients with Dementia Due to Normal Pressure Hydrocephalus....Pages 456-461
Back Matter....Pages 463-472
Neurology; Pathology; Pharmacology/Toxicology; Neurosciences; Psychiatry
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