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Cerebral alteration in calmodulin levels associated with the induction of physical dependence upon ethanol in rats

โœ Scribed by Harish C. Pant; Edward Majchrowicz; Mridulika Virmani


Book ID
118870854
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
183 KB
Volume
342
Category
Article
ISSN
0006-8993

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Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity