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Alteration in serum tyrosine and tryptophan concentrations associated with the induction of physical dependence on ethanol in mice

✍ Scribed by Carlos Abu-Murad; John M. Littleton


Book ID
115773935
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
224 KB
Volume
27
Category
Article
ISSN
0006-2952

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Temporal relationship of the induction o
✍ Edward Majchrowicz; Walter A. Hunt πŸ“‚ Article πŸ“… 1976 πŸ› Springer 🌐 English βš– 576 KB

Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity