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Cerebellar herniation after intrathecal chemotherapy including cytosine arabinoside in a boy with T acute lymphoblastic leukemia

✍ Scribed by Legrand, F; Dorgeret, S; Saizou, C; Duval, M; Vilmer, E

Book ID
110055129
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
108 KB
Volume
16
Category
Article
ISSN
0887-6924

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We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support