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Seizures following intrathecal cytosine arabinoside in young children with acute lymphoblastic leukemia

✍ Scribed by O. B. Eden; W. Goldie; T. Wood; E. Etcubanas


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
680 KB
Volume
42
Category
Article
ISSN
0008-543X

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## Abstract Three groups of children with acute lymphoblastic leukemia (ALL) were treated with intermittent cyclophosphamide, vincristine, cytosine arabinoside, and prednisone (COAP). Group A (no prior relapse) and Group B (prior single‐agent relapse) received COAP after 12 months on another chemot

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Problem. Therapy of children with relapsed acute lymphoblastic leukemia (ALL) not achieving a second remission (CR2) after an initial reinduction attempt is problematic. Methods. 52 children with ALL in first relapse received high-dose cytosine arabinoside and L-asparaginase (HDAraC/L-Asp) after fa