✦ LIBER ✦

Cellular aspects of the action of cytosine arabinoside

✍ Scribed by Valeriote, Fred

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 984 KB
Volume: 10
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950100704

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✦ Synopsis

The cellular effects of Ara-C are reviewed including its S-phase sensitivity, its proliferative-dependent cytotoxicity and progression delay effects which result in unbalance growth. Both direct and indirect cytotoxic mechanisms are discussed.

The impact of such cellular information on the scheduling of Ara-C is presented with regard to normal and tumor cell population cytotoxicity. Based on these data a therapeutic rationale is presented.

Key words phase-specific, cell kinetics, drug scheduling, progression delay, therapeutic rationale

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