𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cellular aspects of early T-cell development

✍ Scribed by Ken Shortman

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
898 KB
Volume
4
Category
Article
ISSN
0952-7915

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✦ Synopsis

Although the nature of the precursor cells seeding the thymus is still uncertain, their immediate progeny in the adult murine thymus have now been isolated. These lymphoid-restricted, prothymocyte-like cells express CD4, but neither CD4 nor CD8 seem to be involved in the early steps of T-cell development. Cytokines produced by stromal cells are likely to be involved in intrathymic T-cell development, but interleukin-2 and interleukin-4 do not appear to be required. There is still no satisfactory cell-culture model of intrathymic T-cell development. Current culture systems reflect only fragments of the process, or are models of extrathymic developmental pathways.

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