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✦   LIBER   ✦

Regulation of the early stages of T-cell development

✍ Scribed by Astar Winoto

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
701 KB
Volume
3
Category
Article
ISSN
0952-7915

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✦ Synopsis

During the past year, there have been rapid advances in our understanding of the early events of T-cell development, at the molecular level. Studies at the transcriptional level of T-cell receptor gene regulation have started to yield important clues about how different T-cell-specific genes can share the same transcription factors and how alpha beta and gamma delta T cells are differentially regulated. In addition, studies using transgenic mice with the T-cell receptor gamma delta genes have further strengthened the separate lineage model of alpha beta and gamma delta T cells and brought into play the importance of negative cis-regulatory elements for lineage-specific determination.

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