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Cellular activation of diaziquone [2,5-diaziridinyl-3,6-bis (carboethoxyamino)- 1,4-benzoquinone] to its free radical species

✍ Scribed by Peter L. Gutierrez; Merrill J. Egorin; Bonnie M. Fox; Rosalind Friedman; Nicholas R. Bachur

Book ID
115778564
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
490 KB
Volume
34
Category
Article
ISSN
0006-2952

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14C]AZQ (2-4 mg/m 2, 100 200 mCi) was administered at varying times to five patients undergoing surgical resection of intracerebral tumors. Plasma, cerebrospinal fluid (CSF), edematous brain, and tumor specimens were obtained during surgery and the concentration of AZQ was determined radiochemically