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Alkylation of DNA by the new anticancer agent 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone (AZQ)

โœ Scribed by King, Cheung Lam; Wong, Sin-Kuen; Loo, Ti Li


Book ID
120362858
Publisher
Elsevier Science
Year
1984
Weight
415 KB
Volume
20
Category
Article
ISSN
0277-5379

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Intracerebral penetration and tissue dis
โœ Niramol Savaraj; Katherine Lu; Lynn G. Feun; Milam E. Leavens; David Stewart; Mi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer US ๐ŸŒ English โš– 344 KB

14C]AZQ (2-4 mg/m 2, 100 200 mCi) was administered at varying times to five patients undergoing surgical resection of intracerebral tumors. Plasma, cerebrospinal fluid (CSF), edematous brain, and tumor specimens were obtained during surgery and the concentration of AZQ was determined radiochemically