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Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes

✍ Scribed by Mei-Fei Yueh; Marleen Kawahara; Judy Raucy

Book ID
116919237
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
350 KB
Volume
19
Category
Article
ISSN
0887-2333

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In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr