Two-stage penetration of a single oral d
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A. Nowak; A. Klimowicz
📂
Article
📅
1990
🏛
Springer
🌐
English
⚖ 411 KB
The time-dependent concentration curves of sulphadimethoxine in plasma and cantharidin-induced skin blister fluid have been evaluated following a single oral dose of 1 g. In contrast to other drugs, sulphadimethoxine exhibited two-stage penetration into the blister fluid, the second peak concentrati