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CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex

✍ Scribed by Alves, Markênia Kélia Santos; Faria, Mário Henrique Girão; Neves Filho, Eduardo Henrique Cunha; Ferrasi, Adriana Camargo; Pardini, Maria Inês de Moura Campos; de Moraes Filho, Manoel Odorico; Rabenhorst, Silvia Helena Barem


Book ID
122488524
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
723 KB
Volume
11
Category
Article
ISSN
1743-9191

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Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes in neoplasms. Recently, O 6 -methylguanine-DNA methyltransferase, MGMT, was shown to be hypermethylated in certain carcinomas, resulting in loss of MGMT prote