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CD48 Delivers an Accessory Signal for CD40-Mediated Activation of Human B Cells

โœ Scribed by Elena N. Klyushnenkova; Li Li; Richard J. Armitage; Yong Sung Choi


Book ID
112239692
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
419 KB
Volume
174
Category
Article
ISSN
0008-8749

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This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of