CD40 and its ligand: Central players in B lymphocyte survival, growth, and differentiation
β Scribed by J. Gordon
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 511 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0268-960X
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B cell differentiation depends on cellular interactions with T lymphocytes and monocytes via adhesion molecules (AM). In order to characterize AM which are required for B cell differentiation immunoglobulin production using unseparated peripheral blood mononuclear cells (PBMC) was studied. Unstimula
## Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth" In the present study, we examined the participation of CD40 ligand (L)-CD40 interaction in T cell-dependent B cell responses. To this end, purified B lymphocytes were cultured over irradiated CD4+ cloned T cel