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Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth

✍ Scribed by Dominique Blanchard; Claude Gaillard; Patrice Hermann; Jacques Banchereau

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
647 KB
Volume
24
Category
Article
ISSN
0014-2980

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✦ Synopsis

Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth"

In the present study, we examined the participation of CD40 ligand (L)-CD40 interaction in T cell-dependent B cell responses. To this end, purified B lymphocytes were cultured over irradiated CD4+ cloned T cells activated with immobilized anti-CD3 antibody. The anti-CD40 mAb 89 strongly blocked, in a specific fashion, both proliferation and Ig secretion of tonsil B cells. Interestingly, proliferation of surface (s)IgD+ B cell was significantly less inhibited by anti-CD40 than that of sIgD-cells. Preactivated T cells induced B cells to grow and secrete immunoglobulins preferentially in response to IL-2. This contrasts with the CD40 system where B cells are essentially responsive to IL-4 and IL-10 but not to IL-2 alone. Collectively, these data indicate that CD40L-CD40 interaction plays an important role in IL-2-mediated T cell-dependent B cell responses. However, the activation of a subset of sIgD+ cells may be independent of this interaction.

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