Cd4+ T cell apoptosis induced by anti-CD4 antibodies
โ Scribed by Zhihong, Zhang ;Yue, Zhang ;Huifen, Zhu ;Jing, Yang ;Guanxin, Shen
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 271 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0257-716X
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๐ SIMILAR VOLUMES
In the presence of interleukin 2 (IL2), soluble anti-CD3 monoclonal antibodies can stimulate highly purified normal T lymphocytes to proliferate. In these experiments HLADR' T cells constituted 13 to 20% of the total cell population, and other HLADR' cells, such as monocytes and B lymphocytes, const
w e investigated whether exposure of naive and in vitro pre-activated T cells to CD4 monoclonal antibodies (mAb) could induce specific hyporesponsiveness to a subsequent challenge in the absence of CD4 mAb. Unfractionated peripheral blood mononuclear cells were cultured with mitomycin-treated B cell