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CD3-induced T-cell activation in the bone marrow of myeloma patients: major role of CD4+ cells

✍ Scribed by ALBERTO BIANCHI; LAURA MONTACCHINI; PAOLA BARRAL; PAOLO BORRIONE; CARMELA ATTLSANO; ENRICA ORSINI; MARIO BOCCADORO; ALESSANDRO PILERI; MASSIMO MASSAIA


Book ID
114714395
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
829 KB
Volume
90
Category
Article
ISSN
0007-1048

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CD4, CD8 and the role of CD45 in T-cell
✍ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta