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CD28-dependent killing by human YT cells requires phosphatidylinositol 3-kinase activation

✍ Scribed by Yiling Lu; Ron Rodriguez; Jay Bjorndahl; Catherine A. Phillips; James M. Trevillyan


Book ID
102825241
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
737 KB
Volume
26
Category
Article
ISSN
0014-2980

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## Abstract T cell activation requires costimulation of TCR/CD3 plus accessory receptors (__e.g.__ CD28). A hallmark of costimulation is the dynamic reorganization of the actin cytoskeleton, important for receptor polarization in the immunological synapse. The classical model of T cell costimulatio