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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

✍ Scribed by Pagès, Françoise ;Ragueneau, Marguerite ;Rottapel, Robert ;Truneh, Alemseged ;Nunes, Jacques ;Imbert, Jean ;Olive, Daniel


Book ID
109789148
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
127 KB
Volume
370
Category
Article
ISSN
0028-0836

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The interaction of CD28 with its counter-receptor, B7-1 (CD 80), on antigenpresenting cells induces a co-signal in T cells required to promote antigendependent interleukin-2 (IL-2) production and to prevent clonal anergy. CD28 stimulation causes both protein-tyrosine kinase and phosphatidylinositol3