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Phosphatidylinositol-3-kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to β1-integrins in human CD34+ cells

✍ Scribed by Sofya Melikova; Scott J. Dylla; Catherine M. Verfaillie

Book ID: 113615837
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 287 KB
Volume: 32
Category: Article
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2004.07.018

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Phosphatidylinositol 3-kinase (Pl-3K) plays a key role in several cellular processes, including mitogenesis, apoptosis, actin reorganization and vesicular trafficking. The molecular events involved in its activation have not been fully elucidated and several reports indicate that a key event for enz