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Cathelicidin LL-37: A Multitask Antimicrobial Peptide

✍ Scribed by Robert Bucki; Katarzyna Leszczyńska; Andrzej Namiot; Wojciech Sokołowski

Publisher
Springer
Year
2010
Tongue
English
Weight
380 KB
Volume
58
Category
Article
ISSN
0004-069X

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✍ Zhifang Zhang; Gregory Cherryholmes; Frances Chang; David M. Rose; Ingrid Schrau 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB

## Abstract LL‐37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL‐37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down‐regulated by LL‐37. LL‐37 functions similarly to CXCR2‐specific chemokines CX