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Catechol- O -Methyltransferase GeneticVariant Associated with the Risk of Alzheimer’s Disease in a Brazilian Population

✍ Scribed by Pereira, Patricia Araújo; Romano-Silva, Marco Aurélio; Bicalho, Maria Aparecida Camargos; de Moraes, Edgar Nunes; Malloy-Diniz, Leandro; Pimenta, Guilherme José Garcia Santos; Mello, Marina Pena; Bozzi, Isadora Cristine Reis Sguizzato; de Marco, Luiz Armando; Nicolato, Rodrigo; Miranda, Debora Marques


Book ID
118239854
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
245 KB
Volume
34
Category
Article
ISSN
1420-8008

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## Abstract ## Background: The A‐allele of the catechol‐__O__‐methyltransferase (__COMT__) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. ## Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent t