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Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease

✍ Scribed by Lonneke M.L. de Lau; Dagmar Verbaan; Johan Marinus; Peter Heutink; Jacobus J. van Hilten

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
1006 KB
Volume
27
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background:

The A‐allele of the catechol‐O‐methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.

Methods:

We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations.

Results:

The A‐allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow‐up, in a dose‐dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07–4.06] and 2.81 [CI, 1.43–5.54], respectively).

Conclusions:

This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. © 2011 Movement Disorder Society

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