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G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease

✍ Scribed by T. Xie; Dr. S. L. Ho; L. S. W. Li; O. C. K. Ma

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
216 KB
Volume
12
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

High and low catechol‐O‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine~108~ polymorphism associated with polymorphic G/A~1947~ bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.

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