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Association of Catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population

✍ Scribed by Wen Jun Li; Chang Gui Kou; Yaqin Yu; Shilong Sun; Xuan Zhang; Thomas R. Kosten; Xiang Yang Zhang

Book ID: 111995334
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 103 KB
Volume: 159B
Category: Article
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.32038

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Several linkage studies suggested chromosome 22q11-13 may harbor susceptible genes for schizophrenia. Catechol-0methyl-transferase t:COMT), which is involved in the metabolism of catecholamines, was mapped to 22q'll and is considered a possible candidate gene for schizophrenia. Recently, we identifi