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Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture

✍ Scribed by Yang Cao; Dawei Wang; Bin Liu; Guijun Yao; Yutuo Fu; Zhenggang Bi


Book ID
106471346
Publisher
Springer
Year
2011
Tongue
English
Weight
187 KB
Volume
39
Category
Article
ISSN
0301-4851

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Catechol-O-methyltransferase Val158Met a
✍ Lonneke M.L. de Lau; Dagmar Verbaan; Johan Marinus; Peter Heutink; Jacobus J. va πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 1006 KB

## Abstract ## Background: The A‐allele of the catechol‐__O__‐methyltransferase (__COMT__) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. ## Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent t