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Negative association between Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia

✍ Scribed by I.-C. Lai; Y.-C. Wang; C.-C. Lin; Y.-M. Bai; D.-L. Liao; S.-C. Yu; C.-Y. Lin; J.-Y. Chen; Y.-J. Liou


Publisher
Springer
Year
2004
Tongue
English
Weight
69 KB
Volume
112
Category
Article
ISSN
1435-1463

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Several linkage studies suggested chromosome 22q11-13 may harbor susceptible genes for schizophrenia. Catechol-0methyl-transferase t:COMT), which is involved in the metabolism of catecholamines, was mapped to 22q'll and is considered a possible candidate gene for schizophrenia. Recently, we identifi