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Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations

✍ Scribed by Hiroshi Yamazaki; Mayumi Mimura; Chikako Sugahara; Tsutomu Shimada

Book ID
115784178
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
389 KB
Volume
48
Category
Article
ISSN
0006-2952

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High expression of cytochrome P450 2a-5
High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas
✍ Valery Kobliakov; Ludmila Kulikova; Dimitri Samoilov; Matti A. Lang 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Abstract A high level of Cyp2a‐5 was found in spontaneous and transplanted mouse hepatomas compared with normal liver. Increased expression of Cyp2a‐5 was associated with an increase in coumarin 7‐hydroxylation, a marker activity of Cyp2a‐5, and the corresponding mRNA, suggesting that regulation