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Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes

✍ Scribed by Z.-Y. LIU; M.-H. DAI; Y.-F. TAO; D.-M. CHEN; Z.-H. YUAN

Book ID: 108885585
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 237 KB
Volume: 34
Category: Article
ISSN: 0140-7783
DOI: 10.1111/j.1365-2885.2010.01262.x

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## Abstract A high level of Cyp2a‐5 was found in spontaneous and transplanted mouse hepatomas compared with normal liver. Increased expression of Cyp2a‐5 was associated with an increase in coumarin 7‐hydroxylation, a marker activity of Cyp2a‐5, and the corresponding mRNA, suggesting that regulation