Catalytic Enantioselective Alkylation of Aldehydes by Using Organozinc Halide Reagents
β Scribed by Kinoshita, Yuichiro; Kanehira, Shinichi; Hayashi, Yasuki; Harada, Toshiro
- Book ID
- 118747099
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 401 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0947-6539
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π SIMILAR VOLUMES
## Abstract The enantioselective addition of organozinc reagents to aromatic and aliphatic aldehydes **1** gives secondary alcohols **2** with excellent enantioselectivities in high yields through the catalytic use of (__R__)β3,3β²βbis(diphenylphosphinoyl)βBINOL (**3**) or (__R__)β3,3β²βbis(diphenylt
## Abstract A general method has been developed for preparing enantioenriched secondary alcohols by starting from aryl bromides and aldehydes. Aryl bromides were first treated with BuLi, and the resulting aryllithium reagents were mixed with titanium tetraisopropoxide and magnesium bromide. The rea